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The Walter Reed Army Institute of Research (WRAIR) is offering a postdoctoral opportunity in the Malaria program within the Drug Discovery Department, Experimental Therapeutics Branch. This postdoctoral opportunity will support an exciting collaboration between WRAIR and the Defense Advanced Research Projects Agency (DARPA). This DARPA-funded research project will focus on artificial intelligence to mine large libraries of small molecules for antimicrobial properties in silico. Within this collaboration, WRAIR will provide in vitro and in vivo testing of these compounds for antimicrobial activity against multidrug-resistant bacteria, parasites, and viruses with the desired goal of collaboratively discovering novel antimicrobial therapies and to confirm hits identified using AI.
As an ORISE participant you will support our mission in executing established in vitro drug screening assays against multidrug-resistant bacteria, and other assays addressing Department goals for antimicrobial (including malaria, bacteria, and/or viruses) drug discovery and development as needed. You will gain hands-on experience in collaboration exchanges, data/results analysis, generation of research reports and manuscripts for publication, along with opportunities for intra- and extramural presentations.
During your appointment you will collaborate with a research team focused on the screening of small molecules for antibacterial activity, and will engage with the antibiotics-section lead, intra- and extramural researchers to coordinate small molecule testing, data analysis, and delivery/discussion of results. Under the guidance of a mentor, you will also execute small-molecule screening assays and subsequent determination of minimum inhibitory concentrations for publications and presentations at scientific conferences. This learning experience will also provide you with additional opportunities for authorship on both collaborative and independent research efforts in antimicrobial drug discovery will be available.
Additional learning objectives will include:
For more information on WRAIR please visit www.wrair.army.mil for more information.
Appointment Length
This appointment is a twelve month research appointment, with the possibility to be renewed for additional research periods. Appointments may be extended depending on funding availability, project assignment, program rules, and availability of the participant.
Participant Benefits
Nature of Appointment
The participant will not enter into an employee/employer relationship with ORISE, ORAU, DOD, or any other office or agency. Instead, the participant will be affiliated with ORISE for the administration of the appointment through the ORISE appointment letter and Terms of Appointment.
Minimum Qualifications:
• Ph.D. or equivalent degree in Biological or Biomedical Sciences with ideally 2-5 years of research experience.
• Excellent written and verbal communication skills
• Background in microbiology/bacteriology.
Preferred Qualifications:
Top-tier candidates will have a strong publication record studying pathogenic and/or multidrug-resistant bacteria, in particular Gram-negative organisms. Experience in drug discovery/testing is an advantage. Desirable qualities include self-motivation, exemplary critical-thinking skills, the ability to troubleshoot assays, as well as an ability to work with others while maintaining a pleasant attitude.
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