*Applications may be reviewed on a rolling-basis and this posting could close before the deadline. Click here for information about the selection process.
EPA Office/Lab and Location: A research opportunity is available at the Environmental Protection Agency (EPA), Office of Research and Development (ORD), Center for Public Health Environmental Assessment (CPHEA), Public Health and Integrated Toxicology Division (PHITD) located in Research Triangle Park, North Carolina.
Research Project: There are more than 100,0000 chemicals that need prioritization for further toxicity testing. It would be very beneficial to develop rapid and sensitive methods to detect neurotoxicity/developmental neurotoxicity. One goal for the Agency is to develop a cost-effective and rapid assay based on sound systems in vitro biology for prioritizing chemicals for subsequent screening and neurotoxicity testing. Although developmental neurotoxicity testing (DNT), which focuses on a limited set of cellular phenotypic responses, has gained a lot of attention recently, understanding the adverse outcome pathways (AOPs; i.e. the underlying molecular mechanisms) in adult animals is vital for adult neurotoxicity testing and to expedite development of models for DNT assessment. We have been working on developing in vitro methods to understand in vivo functional and morphological outcomes. Research has focused on understanding the changes from the molecular -> cellular -> organ -> whole animal responses. Understanding multiple toxicity pathways at the same time is facilitated by current developments in genomic (study of all genes in an organism), proteomic (study of all proteins in an organism) and modeling technologies.
The research participant will have the opportunity to be involved in projects identifying the AOPs for selected neurotoxicants through proteomic and genomic analysis in vitro using neuronal cultures as well as in vivo in whole animal studies. Under the guidance of mentor, the research participant will be trained in evaluating neurochemical, molecular, and transcriptomic changes occurring following exposure to chemicals in vitro and in vivo. Moreover, the research participant will be trained in analyzing data and writing research publications. The research project will be closely integrated with ongoing projects in PHITD and collaborators in the CPHEA.
Learning Objectives: The research participant will have the opportunity to develop skills in designing, conducting, analyzing, and interpreting data for communication to the broader scientific audience. The research participant will have opportunities to present research findings at major society conferences and interact with a broad group of scientists at the EPA and elsewhere.
Mentor(s): The mentor for this opportunity is Dr. Prasada Kodavanti (firstname.lastname@example.org). If you have questions about the nature of the research please contact the mentor(s).
Anticipated Appointment Start Date: Fall 2020. All start dates are flexible and vary depending on numerous factors. Click here for detailed information about start dates.
Appointment Length: The appointment will initially be for one year and may be renewed up to three or four additional years upon EPA recommendation and subject to availability of funding.
Level of Participation: The appointment is full-time.
Participant Stipend: The participant will receive a monthly stipend commensurate with educational level and experience. Click here for detailed information about full-time stipends.
EPA Security Clearance: Completion of a successful background investigation by the Office of Personnel Management (OPM) is required for an applicant to be on-boarded at EPA.
ORISE Information: This program, administered by ORAU through its contract with the U.S. Department of Energy (DOE) to manage the Oak Ridge Institute for Science and Education (ORISE), was established through an interagency agreement between DOE and EPA. Participants do not become employees of EPA, DOE or the program administrator, and there are no employment-related benefits. Proof of health insurance is required for participation in this program. Health insurance can be obtained through ORISE.
Questions: Please see the FAQ section of our website. After reading, if you have additional questions about the application process please email EPArpp@orau.org and include the reference code for this opportunity.
The qualified candidate should have received a bachelor's or master's degree in one of the relevant fields, or be currently pursuing the degree with completion by October 2020. Degree must have been received within five years of the appointment start date.