*Applications may be reviewed on a rolling-basis and this posting could close before the deadline. Click here for information about the selection process.
EPA Office/Lab and Location: A research opportunity is available at the Environmental Protection Agency (EPA), Office of Research and Development (ORD), Center for Computational Toxicology and Exposure (CCTE), Great Lakes Toxicology & Ecology Division (GLTED) located in Duluth, Minnesota.
Research Project: PFAS chemicals have been identified as contaminants of emerging concern and currently lack toxicological data necessary for decision making. EPA is mandated to address the endocrine disrupting potential of chemicals and a growing body of evidence suggests that some PFAS chemicals can disrupt thyroid function. For the majority of PFAS chemicals there is a lack of information regarding whether they have the potential to cause adverse effects from impacts on thyroid hormone status. Understanding the important molecular targets within the network of processes involved in maintaining normal functioning thyroid hormone levels, and what approaches to best assess activity at those targets are critical to developing a comprehensive approach to evaluating thyroid hormone disrupting potential of large numbers of chemicals.
This research aims to utilize a recently developed battery of in vitro high-throughput screening (HTS) assays to interrogate chemical activity toward various biochemical mechanisms critical to thyroid function. This will include six thyroid-related HTS assays to screen a PFAS chemical library and determine the potential for PFAS chemicals to inhibit these thyroid-related targets. Further, this research aims to utilize these in vitro PFAS activity data, together with an in vitro-to-in vivo translational framework to predict which PFAS compounds have the highest likelihood of causing thyroid disruption in aquatic vertebrates. Coordinated efforts will be undertaken in the mammalian model in parallel to these efforts to bolster cross-species concordance of PFAS modes of action and adverse outcome pathways (AOPs) related to thyroid disruption.
Learning Objectives: The participant will be integrated into a transdisciplinary research team and engaged in multiple aspects of project planning, communication and coordination, research implementation, and analysis. The participant will be afforded an opportunity to interact with internationally recognized leaders, both within and outside EPA. The participant may contribute to and/or publish original research. The participant will gain knowledge, skills, and abilities needed to apply new technologies and associated data to regulatory decision-making at the local, national, and/or international scale and to pursue a professional career in life sciences research.The participant will learn a diversity of laboratory, analytical, and computational techniques which can be applied across life sciences research fields. The participant will learn to operate and use a range of scientific equipment. The participant will learn to evaluate data quality, troubleshoot research results, apply statistical methods for data analysis and interpretation.
Mentor(s): The mentor for this opportunity is Sigmund Degitz (firstname.lastname@example.org). If you have questions about the nature of the research please contact the mentor(s).
Anticipated Appointment Start Date: Summer/Fall 2021. All start dates are flexible and vary depending on numerous factors. Click here for detailed information about start dates.
Appointment Length: The appointment will initially be for one year and may be renewed up to three or four additional years upon EPA recommendation and subject to availability of funding.
Level of Participation: The appointment is full-time.
Participant Stipend: The participant will receive a monthly stipend commensurate with educational level and experience. Click here for detailed information about full-time stipends.
EPA Security Clearance: Completion of a successful background investigation by the Office of Personnel Management (OPM) is required for an applicant to be on-boarded at EPA.
ORISE Information: This program, administered by ORAU through its contract with the U.S. Department of Energy (DOE) to manage the Oak Ridge Institute for Science and Education (ORISE), was established through an interagency agreement between DOE and EPA. Participants do not become employees of EPA, DOE or the program administrator, and there are no employment-related benefits. Proof of health insurance is required for participation in this program. Health insurance can be obtained through ORISE.
Questions: Please see the FAQ section of our website. After reading, if you have additional questions about the application process please email ORISE.EPA.ORD@orau.org and include the reference code for this opportunity.
The qualified candidate should have received a doctoral degree in one of the relevant fields, or be currently pursuing the degree and will reach completion by the start of the appointment. Degree must have been received within five years of the appointment start date.