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A research opportunity is currently available at the U.S. Environmental Protection Agency’s (EPA) Office of Research and Development (ORD)/National Health and Environmental Effects Research Laboratory (NHEERL). This appointment will be served with the Mid-Continent Ecology Division (MED) in Duluth MN.
The lack of established water quality criteria or guidelines for many contaminants of emerging concern (CECs) in surface waters represents a significant challenge to state and regional risk assessors charged with protecting our nation’s waters and associated aquatic ecosystems from harmful impacts of toxic chemicals. For example, recent contaminant and biological effects surveillance on the South Platte and Colorado rivers in Colorado and Utah have detected complex mixtures of contaminants and estrogen receptor (ER), glucocorticoid receptor (GR), and peroxisome proliferator activated receptor (PPAR)-mediated biological activities in surface waters downstream of municipal waste-water treatments plants. Chemicals responsible for these biological activities, their spatial and temporal variation in relation to discharge and flows, the potential hazards those activities pose to resident aquatic organisms, and whether there are adverse biological effects occurring in exposed organisms are unknown. The research participant will be involved in research aimed at using biological pathway-based tools and approaches being developed through EPA’s Chemical Safety for Sustainability Research program to address these unknowns.
The research participant may be involved in any or all of the following training activities:
The research participant will learn diverse laboratory techniques which can be applied across life sciences research fields. The research participant will learn to operate and use a range of scientific equipment. The research participant will learn to evaluate data quality, trouble shoot research results, apply statistical methods for data analysis and interpretation.
The participant will be integrated into a transdiciplinary research team and engaged in multiple aspects of project planning, communication and coordination, research implementation, and analysis. The research participant will be afforded an opportunity to interact with internationally recognized leaders, both within and outside EPA, in the area of applying adverse outcome pathway knowledge to the practice of chemical risk assessment with a particular focus on applications to effects-based surveillance and monitoring. The research participant will have the opportunity to contribute to and/or publish original research on novel adverse outcome pathways relevant to aquatic ecotoxicology. It is expected that this training opportunity will provide an early career scientist with knowledge, skills, and abilities needed to apply new technologies and associated data to regulatory decision-making at the local, national, and/or international scale and to pursue graduate education or a professional career in life sciences research.
The appointment is full-time for one year and may be renewed upon recommendation of EPA and contingent on the availability of funds. The participant will receive a monthly stipend. Funding may be available to reimburse the participant’s travel expenses to present the results of his/her research at scientific conferences. No funding will be available to cover travel costs for pre-appointment visits, relocation costs, tuition and fees, or participant’s health insurance. The participant must show proof of health and medical insurance. The participant does not become an EPA employee.
The mentors for this project are Dan Villeneuve (villeneuve.dan@epa.gov). The desired start date is March 19, 2018.
Applicants must have received a bachelor's degree biology, (eco)toxicology, biochemistry, molecular biology, genetics, chemistry, or a related field within five years of the desired starting date. Research experience, cell culture experience (e.g., plating, maintaining, freezing animal cells using aseptic technique), and experience with basic molecular biology techniques used for analysis of proteins and nucleic acids (e.g., gel electrophoresis, PCR, quantitative real-time PCR, use of thermocyclers and/or bioanalyzers, etc.) are desirable.
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