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A postdoctoral research opportunity is currently available at the U.S. Environmental Protection Agency’s (EPA) Office of Research and Development (ORD). The appointment will be served with the National Center for Computational Technology (NCCT) in Research Triangle Park, NC.
NCCT is responsible for developing new computational tools and providing quantitative analysis for improving environmental risk assessments and regulatory decisions pertaining to chemical safety and sustainability. NCCT has newly formed an experimental arm with the focus of developing new high-throughput and/or high-content assays as well as exploring increasingly complex cell culture systems that more accurately reflect human physiology. This project aims to develop a library of cell cultures to be readily available for large-scale chemical screening for the purpose of performing high-throughput whole genome transcriptomics as well as develop additional complex cell culture systems and analysis techniques for future applications.
The participant will collaborate with a multidisciplinary research team including scientists at EPA and other partners. The participant will be involved in the following activities:
developing a library of stable, high quality and reproducible cell cultures
developing protocols for chemical screening of these cell cultures across hundreds or thousands of chemicals
developing experimental protocols which support dose-response assessments of transcriptomic and other cell-based assay endpoints
developing complementary in vitro analysis techniques and strategies to aid in chemical screening and targeted follow-up studies
developing or adapting complex culture systems for future screening applications.
The ToxCast research program has generated bioactivity data on thousands of chemicals across roughly one thousand assay endpoints. It is recognized that although these assays cover a large swath of biology they are not exhaustive and do not always provide a diverse cellular context. The resulting data will be used to support the chemical prioritization and safety assessment process.
The participant will be collaborating with a multidisciplinary research team including scientists at EPA and other partners. A research plan will be developed and the project will be conducted under the guidance of a mentor. The participant will have latitude in exercising independent initiative and judgment in the research commensurate with the level of training.
Through this project, the participant will gain experience in the general areas of cell culture experimentation, high-throughput screening of large chemical libraries, laboratory robotics, global transcriptomics and other complementary molecular biology techniques. Research findings will be communicated through peer-reviewed publications, national meetings of professional societies, and work-in-progress seminars.
This program, administered by ORAU through its contract with the U.S. Department of Energy to manage the Oak Ridge Institute for Science and Education, was established through an interagency agreement between DOE and EPA.
Applicants must have received a doctoral degree in biology, biochemistry, genetics, toxicology or a related field within five years of the desired starting date, or completion of all requirements for the degree should be expected prior to the starting date. Knowledge and practical experience using either clonal mammalian cell lines or primary cell cultures in previous research is desired.
The appointment is full-time for one year and may be renewed upon recommendation of EPA and contingent on the availability of funds. The participant will receive a monthly stipend. Funding may be available to reimburse the participant’s travel expenses to present the results of his/her research at scientific conferences. No funding will be available to cover travel costs for pre-appointment visits, relocation costs, tuition and fees, or participant’s health insurance. The participant must show proof of health and medical insurance. The participant does not become an EPA employee.
The mentors for this project are Matt Martin (martin.matt@epa.gov) and Chad Deisenroth (deisenroth.chad@epa.gov). The desired start date is July 1, 2016.
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