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CDC Office and Location: A research and training opportunity is available in the Poxvirus and Rabies Branch (PRB), Division of High-Consequence Pathogens and Pathology (DHCPP) of the National Centers for Emerging and Zoonotic Infectious Diseases (NCEZID) at the Centers for Disease Control and Prevention (CDC) located in Atlanta, Georgia.
The Centers for Disease Control and Prevention (CDC) is one of the major operation components of the Department of Health and Human Services. CDC works to protect America from health, safety and security threats, both foreign and in the U.S. Whether diseases start at home or abroad, are chronic or acute, curable or preventable, human error or deliberate attack, CDC fights disease and supports communities and citizens to do the same.
Research Project: The Poxvirus and Rabies Branch is responsible for consultation, disease surveillance, and investigations related to poxviruses and rabies viruses. We serve as World Health Organization (WHO) Collaborating as one of two WHO Collaborating Centers for Smallpox and other Poxvirus Infections, the WHO Collaborating Center for Reference and Research on Rabies, and the World Organization for Animal Health (OIE) reference laboratory for rabies.
To support our mission, our laboratories perform nucleic acid and serologic based diagnostic testing, undertake research and development of novel assays, and engage in animal studies designed to elucidate viral mechanisms and anti-viral compound efficacy. We are seeking a research fellow to assist the Immunodiagnostics and Proteomics Team for a period of 2-3 years. The fellow will utilize common and novel serology techniques for diagnostic testing to confirm prior infection or vaccination by pox- and rabies viruses. We utilize a variety of techniques to characterize serologic responses including ELISA, blotting, and virus neutralization assays (PRNT, or plaque reduction and neutralization titration) to detail immune response and to detect viruses. We incorporate modern technologies such as protein microarrays, Luminex, and MSD to aid in these endeavors, and utilize automated liquid handling equipment (Tecan Evo ELISA) to automate assays and workflows.
The research fellow will perform diagnostic testing for poxviruses, including learning CLIA and ISO standards required for lab accreditation. They will use tissue culture to grow and purify viruses for comparison with recombinantly expressed proteins by ELISA and other assays to assess sensitivity and specificity gains. One key project will be to complete our transition into automated workflows to eliminate hands-on time for our assays. Opportunities to participate in one or more independent and group projects of the fellow’s interest will also be provided and could include: use of animal model systems to understand pox- or rabies- virus pathogenesis, participation and field investigations or study protocols in national and international locations, or in design and assessment of cutting-edge technologies for application in our laboratories. Publication of findings from clinical testing, ongoing collaborations, and independent research is anticipated. Experience from these efforts will provide the fellow experience and a robust base for future graduate or medical school plans.
Learning Objectives: ORISE PRB Learning Objectives:
The qualified candidate should have received a bachelors, master’s, or doctoral degree in one of the relevant fields (e.g. Biology, Chemistry, Molecular and Cellular Biology, Microbiology, Engineering), or be currently pursuing one of the degrees with completion by May 31, 2023. Most recent degree must have been received in the past five years.
Preferred Skills:
I certify that I have not previously been employed by CDC or by a contractor working directly for CDC. I understand that CDC does not permit individuals with a prior employment relationship with CDC or its contractors to participate as trainees in the ORISE program. (Exceptions may be granted for individuals who, since the previous CDC employment, have obtained a new STEM degree which necessitates training in a new field.)
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